:: Causes Of Mesothelioma ::

Mesothelioma is the growth of malignant cells in mesothelium, the thin membrane covering the body’s internal organs. This mesothelium lining covers the pleural, peritoneal and pericardial cavities. Pleura is a membrane covering the lungs and it is the most common location where mesothelioma cancer occurs also known as pleural mesothelioma. Peritoneum, the protective covering that lines the abdominal cavity may also develop malignant tumors and cause peritoneal mesothelioma.

Mesothelioma is one of the rarest cancers in the world that is caused only by exposure to asbestos. Its exposure can be direct, by inhalation of asbestos or indirect exposure in which the asbestos particles are inhaled from the clothing, hair, equipment or other articles that were previously exposed to asbestos

Causes of Mesothelioma
Asbestos is a naturally occurring fibrous mineral that is mined in different parts of the world due to its wide utility in various industries. However, it is a deadly carcinogen too and a mojor cause of mesothelioma and asbestosis.

Asbestos fibers are known to cause cancer of the mesothelium. Asbestos is the fibrous form of several minerals and hydrous silicates of magnesium found under ground. There are 3 types of asbestos, the blue one, the while one and the brown one. Of all these 3 types, the blue one also called amphibole, long and thin in structure is more carcinogenic than white or chrysolite asbestos or the brown one known as amosite.

However, in some cases the brown asbestos has also been found to cause mesothelioma. And it is for this reason that people exposed to asbestos even for a short period are vulnerable to the disease.

Pleural Mesothelioma
Asbestos fibers are very fine and easily make their way to the lungs where they settle down in the parenchyma of the lung and penetrate the pleura that later develops malignant mesothelial plaques.

Pleura, which anchors lungs to the chest cavity, is itself a double-layered membrane. The inner layer called visceral pleura surrounds the lungs, while the outer one, known as parietal pleura, forms the lining of the pleural or chest cavity. The two pleural layers are filled with a fluid that helps them to slide over each other as we breathe. As the disease progresses, the delicate pleural membranes thicken and press the lungs. A fluid secreted by the malignant cells, pleural effusion, may also collect between visceral and parietal pleurae that causes problem in breathing and other complications.

Peritoneum Mesothelioma
The asbestos fibers may also cause cancer in the peritoneum, known as peritoneal mesothelioma. This leads to thickening of the membranes surrounding abdominal organs and collection of a fluid, ascites in the abdominal cavity making it swell.

Though it is yet not clear how peritoneal mesothelioma develops, it is believed that from lungs, the asbestos fibers are transported to abdomen and its organs by the lymphatic system or they may be deposited in the gut through saliva contaminated by the asbestos fibers.

Pericardial Mesothelioma
This is the rarest type of mesothelioma cancer that comprises of only 5% of all the mesothelioma cases. Like other types of mesothelioma cancer, pericardial mesothelioma is also caused by the inhalation of asbestos dust and fibers. The lining of the chest cavity which protects the heart is known as pericardium. It is provided with a natural fluid or mucous that provide continuous lubrication to the heart so that it can work properly and perform its functions.

It is a very deadly disease that destroys the tissues around the heart and diminishes the survival chances of the patient. As the asbestos particles settle further into the lining of the chest or pericardial, the cancer spreads in the body. It destroys the heart tissues and muscles that is very hazardous to life and proves fatal for the patient.

Author: Jennifer White

:: Pleural Mesothelioma ? Cancer of the Lung Lining ::

Pleural Mesothelioma or malignant pleural mesothelioma is cancer in the layer of the lungs that can spread to the lungs. The spread of the tumor over the pleura results in pleural thickening. This hinders the reflexivity of the pleura and encases the lungs in an increasing restrictive belt. With the lungs thus restricted, they get constricted in no time and a person is always out of breath.

Pleural mesothelioma can be:
- Diffuse and malignant (carcinogenic)
- Localized and benign (non-cancerous)

Benign pleural mesothelioma can be removed surgically, but the malignant tumors are the real terror heads.

Most common among other mesothelioma cases, Pleural Mesothelioma is caused due to exposure to blue asbestos for a longer period of time, say 20 years, in which time the disease incubates only to show its fearful countenance via certain symptoms.

The symptoms of Pleural Mesothelioma
The symptoms of Pleural Mesothelioma include difficulty in breathing, difficulty in sleeping, pain in the chest and abdominal regions, blood vomits, weakness, weight loss, loss of appetite, lower back pains, persistent coughing, hoarseness of voice, sensory loss and difficulty in swallowing.

Diagnosis of Pleural Mesothelioma
The first step is to go through a chest X-ray or a CT scan (computed chest tomograph), which will reveal a pleural thickening and an effusion. This is followed by a bronchoscopy. However, it should always be left to a medical practitioner for a better understanding of the respective cases. Another method is a biopsy, which can be a needle biopsy, an open biopsy, or a thoracoscopy, where a mini camera is inserted inside the body and with that a tissue sample is attained for further diagnosis.


Treatment of Pleural Mesothelioma
Treatment is directly proportional to the time of the revelation of the disease, i.e., at an early stage the tumor can be removed through surgery.

A pioneering mesothelioma treatment option is immunotherapy, e.g., intrapleural inoculation of Bacillus Calmette-Guerin (BCG) is a useful mesothelioma treatment in which an effort is made to intensify the immune response.

Radiation treatment and chemotherapy is probably then the answer to the malignant pleural mesothelioma, but this can aid the pain management only; there's no escaping death with Pleural Mesothelioma.

Side effects of Treatment
The side effects and penalty of mesothelioma lung cancer treatment are more than its treatment, which is damaged healthy tissues, a state of absolute fatigue ness; excessive radiation causes the skin to become red, dry and itchy.

Other side effects of radiotherapy are nausea and vomiting, diarrhea, urinary discomfort and a sudden reduction in the number of white blood corpuscles.

The average life span of a person with Pleural Mesothelioma is up to 6 months to a year and the maximum can reach up to 5 years - the magnesium-silicate mineral fibers take its toll that's more than painful.

Other factors that may accelerate the possibility of pleural mesothelioma are chronic lung infections, tuberculous pleuritis, radiation (Thorotrast), exposure to the simian virus 40 (SV40) or mineral fibers (Zeolite) and tobacco smoking to a certain extent.

Pleural Mesothelioma does not give a person the avenue for fair play. Though the existence depends much on the various stages of the disease, it is an ultimate killing menace that sucks out the life of the common man.

Author: Fred Lindell